Assay Detail
Binding
CHEMBL645067
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Binding affinity towards calf spleen adenosine deaminase was determined
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Spleen |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Inhibition of adenosine deaminase by novel 5:7 fused heterocycles containing the imidazo[4,5-e][1,2,4]triazepine ring system: a structure-activity relationship study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.26 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284483 | COFORMYCIN | 2.0 | 1 | 11.00 |
| CHEMBL9435 | — | — | 1 | 4.92 |
| CHEMBL9381 | — | — | 1 | 4.82 |
| CHEMBL9436 | — | — | 1 | 4.70 |
| CHEMBL267463 | — | — | 1 | 4.64 |
| CHEMBL276651 | — | — | 1 | 4.62 |
| CHEMBL429009 | — | — | 1 | 4.52 |
| CHEMBL9234 | — | — | 1 | 4.11 |
| CHEMBL9700 | — | — | 1 | 4.03 |
| CHEMBL1580 | PENTOSTATIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284483 | COFORMYCIN | Ki | = | 0.01 | nM | 11.00 |
| CHEMBL9435 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL9381 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL9436 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL267463 | — | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL276651 | — | Ki | = | 24000.0 | nM | 4.62 |
| CHEMBL429009 | — | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL9234 | — | Ki | = | 77000.0 | nM | 4.11 |
| CHEMBL9700 | — | Ki | = | 93000.0 | nM | 4.03 |
| CHEMBL1580 | PENTOSTATIN | Ki | = | 0.001 | nM | - |