Assay Detail
Binding
CHEMBL645068
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Compound was evaluated for inhibition of calf intestinal mucosa adenosine deaminase (ADA)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Intestinal mucosa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Adenosine deaminase inhibitors. Synthesis and biological evaluation of aralkyladenines (ARADS).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.23 | 9.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42063 | — | — | 1 | 9.29 |
| CHEMBL295003 | — | — | 1 | 9.12 |
| CHEMBL295417 | — | — | 1 | 9.05 |
| CHEMBL43742 | — | — | 1 | 9.02 |
| CHEMBL418074 | — | — | 1 | 8.99 |
| CHEMBL296435 | (+)-EHNA | — | 1 | 8.70 |
| CHEMBL43226 | — | — | 1 | 6.88 |
| CHEMBL2310914 | — | — | 1 | 6.52 |
| CHEMBL43261 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42063 | — | Ki | = | 0.51 | nM | 9.29 |
| CHEMBL295003 | — | Ki | = | 0.76 | nM | 9.12 |
| CHEMBL295417 | — | Ki | = | 0.89 | nM | 9.05 |
| CHEMBL43742 | — | Ki | = | 0.95 | nM | 9.02 |
| CHEMBL418074 | — | Ki | = | 1.02 | nM | 8.99 |
| CHEMBL296435 | (+)-EHNA | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL43226 | — | Ki | = | 133.0 | nM | 6.88 |
| CHEMBL2310914 | — | Ki | = | 302.0 | nM | 6.52 |
| CHEMBL43261 | — | Ki | = | 302.0 | nM | 6.52 |