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Assay Detail

CHEMBL645071

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Compound was tested for the inhibition of Adenosine deaminase from calf intestine.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Adenosine deaminase (CHEMBL2966)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Purine and 1-deazapurine ribonucleosides and deoxyribonucleosides: synthesis and biological activity.
Cristalli G, Vittori S, Eleuteri A, Grifantini M, Volpini R, Lupidi G, Capolongo L, Pesenti E.
J Med Chem (1991) 34 : 2226 -2230
PubMed 2066996 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 4 5.73 6.57

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3142245 1 6.57
CHEMBL2113394 1 5.92
CHEMBL3142249 1 5.28
CHEMBL612157 1 5.16

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3142245 Ki = 270.0 nM 6.57
CHEMBL2113394 Ki = 1200.0 nM 5.92
CHEMBL3142249 Ki = 5300.0 nM 5.28
CHEMBL612157 Ki = 6900.0 nM 5.16