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Assay Detail

CHEMBL645074

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro inhibition of adenosine deaminase isolated from calf intestine.
19
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Adenosine deaminase (CHEMBL2966)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Adenosine deaminase inhibitors: synthesis and structure-activity relationships of 2-hydroxy-3-nonyl derivatives of azoles.
Cristalli G, Eleuteri A, Volpini R, Vittori S, Camaioni E, Lupidi G.
J Med Chem (1994) 37 : 201 -205
PubMed 8289197 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 19 5.88 8.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL50378 EHNA 1 8.15
CHEMBL18838 1 8.00
CHEMBL17825 1 7.46
CHEMBL18496 1 6.80
CHEMBL65628 2 6.52
CHEMBL292750 2 6.22
CHEMBL64503 2 6.16
CHEMBL65627 2 5.02
CHEMBL64502 2 4.62
CHEMBL62360 1 4.58
CHEMBL17822 1 4.15
CHEMBL293222 1 -
CHEMBL62541 1 -
CHEMBL18659 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL50378 EHNA Ki = 7.0 nM 8.15
CHEMBL18838 Ki = 10.0 nM 8.00
CHEMBL17825 Ki = 35.0 nM 7.46
CHEMBL18496 Ki = 160.0 nM 6.80
CHEMBL65628 Ki = 300.0 nM 6.52
CHEMBL292750 Ki = 600.0 nM 6.22
CHEMBL64503 Ki = 700.0 nM 6.16
CHEMBL65628 Ki = 1000.0 nM 6.00
CHEMBL64503 Ki = 1800.0 nM 5.75
CHEMBL65627 Ki = 9600.0 nM 5.02
CHEMBL292750 Ki = 15000.0 nM 4.82
CHEMBL64502 Ki = 24000.0 nM 4.62
CHEMBL62360 Ki = 26000.0 nM 4.58
CHEMBL17822 Ki = 71000.0 nM 4.15
CHEMBL64502 Ki = 100000.0 nM 4.00
CHEMBL62541 Ki > 1000000.0 nM -
CHEMBL293222 Ki > 400000.0 nM -
CHEMBL18659 Ki = 400000.0 nM -
CHEMBL65627 Ki > 1000000.0 nM -