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Assay Detail

CHEMBL645076

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Adenosine deaminase (ADA) of calf intestine
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 9 — Direct single protein target
Curated By Expert

Target

Adenosine deaminase (CHEMBL2966)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Adenosine deaminase inhibitors: synthesis and biological evaluation of unsaturated, aromatic, and oxo derivatives of (+)-erythro-9-(2'S-hydroxy-3'R-nonyl)adenine [(+)-EHNA].
Pragnacharyulu PV, Varkhedkar V, Curtis MA, Chang IF, Abushanab E.
J Med Chem (2000) 43 : 4694 -4700
PubMed 11101360 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 7.91 9.29

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL42063 1 9.29
CHEMBL295003 1 9.12
CHEMBL295417 1 9.05
CHEMBL43742 1 9.02
CHEMBL418074 1 8.99
CHEMBL296435 (+)-EHNA 1 8.95
CHEMBL81390 1 8.43
CHEMBL81378 1 7.29
CHEMBL606664 1 7.03
CHEMBL606665 1 6.91
CHEMBL43226 1 6.88
CHEMBL311182 1 6.73
CHEMBL2310914 1 6.52
CHEMBL43261 1 6.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL42063 Ki = 0.51 nM 9.29
CHEMBL295003 Ki = 0.76 nM 9.12
CHEMBL295417 Ki = 0.89 nM 9.05
CHEMBL43742 Ki = 0.95 nM 9.02
CHEMBL418074 Ki = 1.02 nM 8.99
CHEMBL296435 (+)-EHNA Ki = 1.13 nM 8.95
CHEMBL81390 Ki = 3.74 nM 8.43
CHEMBL81378 Ki = 50.7 nM 7.29
CHEMBL606664 Ki = 93.1 nM 7.03
CHEMBL606665 Ki = 123.4 nM 6.91
CHEMBL43226 Ki = 133.0 nM 6.88
CHEMBL311182 Ki = 188.0 nM 6.73
CHEMBL2310914 Ki = 302.0 nM 6.52
CHEMBL43261 Ki = 302.0 nM 6.52