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Assay Detail

CHEMBL645081

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of calf intestinal adenosine deaminase
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Adenosine deaminase (CHEMBL2966)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Adenosine deaminase inhibitors: synthesis and structure-activity relationships of imidazole analogues of erythro-9-(2-hydroxy-3-nonyl)adenine.
Cristalli G, Eleuteri A, Franchetti P, Grifantini M, Vittori S, Lupidi G.
J Med Chem (1991) 34 : 1187 -1192
PubMed 2002459 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 28 5.65 8.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL50378 EHNA 1 8.15
CHEMBL18496 1 8.00
CHEMBL17825 1 7.45
CHEMBL18433 1 7.33
CHEMBL18078 1 6.90
CHEMBL18838 1 6.80
CHEMBL17889 1 6.43
CHEMBL115824 1 6.18
CHEMBL18188 1 6.03
CHEMBL17870 1 5.98
CHEMBL18014 1 5.60
CHEMBL276073 1 5.59
CHEMBL279149 1 5.40
CHEMBL18119 1 5.16
CHEMBL18131 1 4.97
CHEMBL17881 1 4.80
CHEMBL17954 1 4.75
CHEMBL17978 1 4.49
CHEMBL18586 1 4.44
CHEMBL276360 1 4.41
CHEMBL273553 1 4.39
CHEMBL440769 1 4.18
CHEMBL17822 1 4.15
CHEMBL18172 1 4.07
CHEMBL202701 1 -
CHEMBL604599 1 -
CHEMBL18367 1 -
CHEMBL18659 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL50378 EHNA Ki = 7.0 nM 8.15
CHEMBL18496 Ki = 10.0 nM 8.00
CHEMBL17825 Ki = 35.3 nM 7.45
CHEMBL18433 Ki = 47.1 nM 7.33
CHEMBL18078 Ki = 126.0 nM 6.90
CHEMBL18838 Ki = 160.0 nM 6.80
CHEMBL17889 Ki = 368.0 nM 6.43
CHEMBL115824 Ki = 660.0 nM 6.18
CHEMBL18188 Ki = 930.0 nM 6.03
CHEMBL17870 Ki = 1040.0 nM 5.98
CHEMBL18014 Ki = 2520.0 nM 5.60
CHEMBL276073 Ki = 2560.0 nM 5.59
CHEMBL279149 Ki = 4020.0 nM 5.40
CHEMBL18119 Ki = 6900.0 nM 5.16
CHEMBL18131 Ki = 10600.0 nM 4.97
CHEMBL17881 Ki = 16000.0 nM 4.80
CHEMBL17954 Ki = 17900.0 nM 4.75
CHEMBL17978 Ki = 32100.0 nM 4.49
CHEMBL18586 Ki = 36300.0 nM 4.44
CHEMBL276360 Ki = 39000.0 nM 4.41
CHEMBL273553 Ki = 41100.0 nM 4.39
CHEMBL440769 Ki = 66000.0 nM 4.18
CHEMBL17822 Ki = 71000.0 nM 4.15
CHEMBL18172 Ki = 86000.0 nM 4.07
CHEMBL202701 Ki = 360000.0 nM -
CHEMBL604599 Ki = 110000.0 nM -
CHEMBL18367 Ki = 347000.0 nM -
CHEMBL18659 Ki = 400000.0 nM -