Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL645083

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Calf intestinal adenosine deaminase (ADA).
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Adenosine deaminase (CHEMBL2966)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

AMP deaminase inhibitors. 5. Design, synthesis, and SAR of a highly potent inhibitor series.
Kasibhatla SR, Bookser BC, Xiao W, Erion MD.
J Med Chem (2001) 44 : 613 -618
PubMed 11170651 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 22 5.71 6.28

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL157669 1 6.28
CHEMBL157723 1 6.14
CHEMBL156756 1 5.57
CHEMBL156990 1 5.47
CHEMBL157800 1 5.43
CHEMBL348608 1 5.36
CHEMBL160174 1 -
CHEMBL160384 1 -
CHEMBL154259 1 -
CHEMBL347030 1 -
CHEMBL158023 1 -
CHEMBL157426 1 -
CHEMBL158136 1 -
CHEMBL157743 1 -
CHEMBL156217 1 -
CHEMBL350676 1 -
CHEMBL346040 1 -
CHEMBL157951 1 -
CHEMBL346360 1 -
CHEMBL157468 1 -
CHEMBL280097 1 -
CHEMBL157949 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL157669 Ki = 530.0 nM 6.28
CHEMBL157723 Ki = 720.0 nM 6.14
CHEMBL156756 Ki = 2700.0 nM 5.57
CHEMBL156990 Ki = 3400.0 nM 5.47
CHEMBL157800 Ki = 3700.0 nM 5.43
CHEMBL348608 Ki = 4400.0 nM 5.36
CHEMBL160174 Ki > 7500.0 nM -
CHEMBL160384 Ki > 7500.0 nM -
CHEMBL154259 Ki > 7500.0 nM -
CHEMBL347030 Ki > 7500.0 nM -
CHEMBL158023 Ki > 7500.0 nM -
CHEMBL157426 Ki > 7500.0 nM -
CHEMBL158136 Ki > 7500.0 nM -
CHEMBL157743 Ki > 7500.0 nM -
CHEMBL156217 Ki > 7500.0 nM -
CHEMBL350676 Ki > 7500.0 nM -
CHEMBL346040 Ki > 7500.0 nM -
CHEMBL157951 Ki > 7500.0 nM -
CHEMBL346360 Ki > 1000000.0 nM -
CHEMBL157468 Ki > 7500.0 nM -
CHEMBL280097 Ki > 7500.0 nM -
CHEMBL157949 Ki > 7500.0 nM -