Assay Detail
Binding
CHEMBL645084
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Inhibitor constant against adenosine deaminase in 0.05 M sodium phosphate buffer at pH 7.0 was determined after heating to 100 degrees celsius
10
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Heat-induced formation of alpha,beta-unsaturated nucleoside dialdehydes and their activity with adenosine deaminase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 4.52 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL349866 | — | — | 1 | 5.10 |
| CHEMBL2304162 | — | — | 2 | 4.70 |
| CHEMBL168001 | — | — | 3 | 4.68 |
| CHEMBL2304163 | — | — | 2 | 4.52 |
| CHEMBL351404 | — | — | 1 | 4.52 |
| CHEMBL353079 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL349866 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL2304162 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL168001 | — | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL2304162 | — | Ki | = | 24000.0 | nM | 4.62 |
| CHEMBL2304163 | — | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL351404 | — | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL168001 | — | Ki | = | 38000.0 | nM | 4.42 |
| CHEMBL168001 | — | Ki | = | 69000.0 | nM | 4.16 |
| CHEMBL2304163 | — | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL353079 | — | Ki | = | 800000.0 | nM | - |