Assay Detail
Binding
CHEMBL645088
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Inhibitory activity against adenosine deaminase in calf intestinal mucosa.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Intestinal mucosa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Adenosine deaminase inhibitors. Synthesis and biological evaluation of chain modified analogs of (+)-EHNA
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.85 | 8.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296435 | (+)-EHNA | — | 1 | 8.95 |
| CHEMBL81390 | — | — | 1 | 8.43 |
| CHEMBL81378 | — | — | 1 | 7.29 |
| CHEMBL311182 | — | — | 1 | 6.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296435 | (+)-EHNA | Ki | = | 1.13 | nM | 8.95 |
| CHEMBL81390 | — | Ki | = | 3.74 | nM | 8.43 |
| CHEMBL81378 | — | Ki | = | 50.7 | nM | 7.29 |
| CHEMBL311182 | — | Ki | = | 188.0 | nM | 6.73 |