Assay Detail
Binding
CHEMBL645097
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Binding affinity against Alpha-1 adrenergic receptor of calf cerebral cortex homogenates using [3H]prazosin
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Cerebral cortex |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and hypoglycemic activity of substituted 8-(1-piperazinyl)imidazo[1,2-a]pyrazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.77 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL554785 | — | — | 1 | 6.52 |
| CHEMBL545289 | — | — | 1 | 6.30 |
| CHEMBL123566 | — | — | 1 | 5.83 |
| CHEMBL555637 | — | — | 1 | 5.75 |
| CHEMBL545293 | — | — | 1 | 5.58 |
| CHEMBL541088 | — | — | 1 | 5.58 |
| CHEMBL538788 | — | — | 1 | 5.56 |
| CHEMBL331036 | — | — | 1 | 5.51 |
| CHEMBL555391 | — | — | 1 | 5.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL554785 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL545289 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL123566 | — | Ki | = | 1490.0 | nM | 5.83 |
| CHEMBL555637 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL545293 | — | Ki | = | 2650.0 | nM | 5.58 |
| CHEMBL541088 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL538788 | — | Ki | = | 2780.0 | nM | 5.56 |
| CHEMBL331036 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL555391 | — | Ki | = | 5430.0 | nM | 5.26 |