Assay Detail
Functional
CHEMBL645196
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic activity against (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Thoracic aorta |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
1,3-dioxolane-based ligands as a novel class of alpha1-adrenoceptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 7.89 | 8.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL286003 | — | — | 1 | 8.65 |
| CHEMBL25554 | — | — | 1 | 8.60 |
| CHEMBL37883 | — | — | 1 | 8.37 |
| CHEMBL287686 | — | — | 1 | 6.93 |
| CHEMBL36978 | — | — | 1 | 6.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL286003 | — | Kd | = | 2.239 | nM | 8.65 |
| CHEMBL25554 | — | Kd | = | 2.512 | nM | 8.60 |
| CHEMBL37883 | — | Kd | = | 4.266 | nM | 8.37 |
| CHEMBL287686 | — | Kd | = | 117.49 | nM | 6.93 |
| CHEMBL36978 | — | Kd | = | 128.82 | nM | 6.89 |