Assay Detail
Functional
CHEMBL645197
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from rat
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Thoracic aorta |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Search for alpha 1-adrenoceptor subtypes selective antagonists: design, synthesis and biological activity of cystazosin, an alpha 1D-adrenoceptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 8.32 | 9.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27013 | — | — | 1 | 9.19 |
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 8.91 |
| CHEMBL29591 | — | — | 1 | 8.54 |
| CHEMBL543741 | — | — | 1 | 8.34 |
| CHEMBL423294 | CYCLAZOSIN | — | 1 | 7.57 |
| CHEMBL29907 | — | — | 1 | 7.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27013 | — | Kd | = | 0.6457 | nM | 9.19 |
| CHEMBL2 | PRAZOSIN | Kd | = | 1.23 | nM | 8.91 |
| CHEMBL29591 | — | Kd | = | 2.884 | nM | 8.54 |
| CHEMBL543741 | — | Kd | = | 4.571 | nM | 8.34 |
| CHEMBL423294 | CYCLAZOSIN | Kd | = | 26.92 | nM | 7.57 |
| CHEMBL29907 | — | Kd | = | 45.71 | nM | 7.34 |