Assay Detail
Functional
CHEMBL645198
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Antagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptor
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships in 1,4-benzodioxan-related compounds. 7. Selectivity of 4-phenylchroman analogues for alpha(1)-adrenoreceptor subtypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 8.08 | 9.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42472 | — | — | 1 | 9.56 |
| CHEMBL25554 | — | — | 1 | 8.80 |
| CHEMBL44403 | — | — | 1 | 8.70 |
| CHEMBL13647 | BMY-7378 | — | 1 | 8.40 |
| CHEMBL42558 | — | — | 1 | 7.78 |
| CHEMBL43905 | — | — | 1 | 7.76 |
| CHEMBL297106 | — | — | 1 | 7.49 |
| CHEMBL40325 | — | — | 1 | 7.21 |
| CHEMBL42231 | — | — | 1 | 7.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42472 | — | Kd | = | 0.2754 | nM | 9.56 |
| CHEMBL25554 | — | Kd | = | 1.585 | nM | 8.80 |
| CHEMBL44403 | — | Kd | = | 1.995 | nM | 8.70 |
| CHEMBL13647 | BMY-7378 | Kd | = | 3.981 | nM | 8.40 |
| CHEMBL42558 | — | Kd | = | 16.6 | nM | 7.78 |
| CHEMBL43905 | — | Kd | = | 17.38 | nM | 7.76 |
| CHEMBL297106 | — | Kd | = | 32.36 | nM | 7.49 |
| CHEMBL40325 | — | Kd | = | 61.66 | nM | 7.21 |
| CHEMBL42231 | — | Kd | = | 91.2 | nM | 7.04 |