Assay Detail

CHEMBL645204

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Binding

In vitro functional activity at Alpha-1D receptor in rat aorta

ChEMBL ↗

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Target

Alpha-1D adrenergic receptor (CHEMBL326) ↗

Open DB target context

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Alpha-1D adrenergic receptor (CHEMBL326) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Alpha-1D adrenergic receptor

CHEMBL326

Anchored from Assay target.

Protein identity Alpha-1D adrenergic receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Tissue	Aorta
Confidence	8 — Homologous single protein target
Curated By	Autocuration

Target

Alpha-1D adrenergic receptor (CHEMBL326) ↗

Type	SINGLE PROTEIN
Organism	Rattus norvegicus

Publication

Two novel and potent 3-[(o-methoxyphenyl)piperazinylethyl]-5-phenylthien.

Carroll WA, Sippy KB, Esbenshade TA, Buckner SA, Hancock AA, Meyer MD.
Bioorg Med Chem Lett (2001) 11 : 1119 -1121
PubMed 11354357 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Kd	1	10.70	10.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL13856	A-123189	—	1	10.70

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL13856	A-123189	Kd	=	0.01995	nM	10.70