Assay Detail
Binding
CHEMBL645296
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Compound was tested for its binding affinity towards brain (neocortex) Adenylate cyclase
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Development of predictive retention-activity relationship models of tricyclic antidepressants by micellar liquid chromatography.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.90 | 7.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL415 | CLOMIPRAMINE | 4.0 | 1 | 7.37 |
| CHEMBL629 | AMITRIPTYLINE | 4.0 | 1 | 7.22 |
| CHEMBL6437 | MIANSERIN | 4.0 | 1 | 7.15 |
| CHEMBL11 | IMIPRAMINE | 4.0 | 1 | 6.80 |
| CHEMBL1628227 | DOXEPIN | 4.0 | 1 | 6.72 |
| CHEMBL445 | NORTRIPTYLINE | 4.0 | 1 | 6.55 |
| CHEMBL72 | DESIPRAMINE | 4.0 | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL415 | CLOMIPRAMINE | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL629 | AMITRIPTYLINE | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL6437 | MIANSERIN | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL11 | IMIPRAMINE | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL1628227 | DOXEPIN | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL445 | NORTRIPTYLINE | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL72 | DESIPRAMINE | Ki | = | 320.0 | nM | 6.50 |