Assay Detail
Binding
CHEMBL645303
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Compound was evaluated for inhibition of vasopressin-stimulated adenylate cyclase in human medullary preparation
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
A minor modification of residue 1 in potent vasopressin antagonists dramatically reduces agonist activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.38 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL384776 | — | — | 1 | 8.44 |
| CHEMBL2371604 | — | — | 1 | 8.41 |
| CHEMBL3084974 | — | — | 1 | 8.37 |
| CHEMBL2371605 | — | — | 1 | 8.35 |
| CHEMBL438014 | — | — | 1 | 8.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL384776 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL2371604 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL3084974 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL2371605 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL438014 | — | Ki | = | 4.6 | nM | 8.34 |