Assay Detail
Functional
CHEMBL645314
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LVP stimulated adenylate cyclase activity in pig kidney medullary membrane
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Sus scrofa |
| Tissue | Feces |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Potent vasopressin antagonists lacking the proline residue at position 7.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.21 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL433614 | — | — | 1 | 8.92 |
| CHEMBL366552 | — | — | 1 | 8.60 |
| CHEMBL409054 | — | — | 1 | 8.57 |
| CHEMBL384776 | — | — | 1 | 8.41 |
| CHEMBL2371680 | — | — | 1 | 8.24 |
| CHEMBL438014 | — | — | 1 | 8.19 |
| CHEMBL369806 | — | — | 1 | 7.89 |
| CHEMBL366473 | — | — | 1 | 7.64 |
| CHEMBL409486 | — | — | 1 | 7.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL433614 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL366552 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL409054 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL384776 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL2371680 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL438014 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL369806 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL366473 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL409486 | — | Ki | = | 41.0 | nM | 7.39 |