Assay Detail
Binding
CHEMBL645479
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards human alpha-2 adrenergic receptor
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Selective optimization of side activities: another way for drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.69 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 8.12 |
| CHEMBL716 | QUETIAPINE | 4.0 | 1 | 7.06 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.80 |
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 6.64 |
| CHEMBL708 | ZIPRASIDONE | 4.0 | 1 | 6.41 |
| CHEMBL285802 | ZOTEPINE | 2.0 | 1 | 6.02 |
| CHEMBL12713 | SERTINDOLE | 4.0 | 1 | 5.78 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL85 | RISPERIDONE | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL716 | QUETIAPINE | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL42 | CLOZAPINE | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL715 | OLANZAPINE | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL708 | ZIPRASIDONE | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL285802 | ZOTEPINE | Ki | = | 960.0 | nM | 6.02 |
| CHEMBL12713 | SERTINDOLE | Ki | = | 1680.0 | nM | 5.78 |
| CHEMBL54 | HALOPERIDOL | Ki | > | 5000.0 | nM | - |