Assay Detail
Binding
CHEMBL645584
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Inhibition of human aromatase cytochrome P450 19A1 activity
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of a new type of non steroidal human aromatase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.24 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9298 | FADROZOLE | 2.0 | 1 | 6.70 |
| CHEMBL9165 | — | — | 1 | 6.70 |
| CHEMBL9179 | — | — | 1 | 6.10 |
| CHEMBL1096024 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9298 | FADROZOLE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL9165 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL9179 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1096024 | — | IC50 | = | 3500.0 | nM | 5.46 |