Assay Detail
Binding
CHEMBL645585
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Inhibition of cytochrome P450 19A1 aromatase from human placental microsomes
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
The synthesis of N-aryl androsterone pyrazoles as aromatase inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.38 | 6.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL132563 | — | — | 1 | 6.63 |
| CHEMBL130546 | — | — | 1 | 6.61 |
| CHEMBL133240 | — | — | 1 | 6.47 |
| CHEMBL132530 | FORMESTANE | 2.0 | 1 | 6.43 |
| CHEMBL129883 | — | — | 1 | 6.31 |
| CHEMBL336383 | — | — | 1 | 6.18 |
| CHEMBL422610 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL132563 | — | IC50 | = | 236.0 | nM | 6.63 |
| CHEMBL130546 | — | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL133240 | — | IC50 | = | 342.0 | nM | 6.47 |
| CHEMBL132530 | FORMESTANE | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL129883 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL336383 | — | IC50 | = | 658.0 | nM | 6.18 |
| CHEMBL422610 | — | IC50 | = | 950.0 | nM | 6.02 |