Assay Detail
Binding
CHEMBL645587
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In vitro inhibition of cytochrome P450 19A1 Aromatase
4
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and aromatase inhibitory activity of novel 1-(4-aminophenyl)-3-azabicyclo[3.1.0]hexane- and -[3.1.1]heptane-2,4- diones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.95 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281947 | — | — | 2 | 8.30 |
| CHEMBL488 | AMINOGLUTETHIMIDE | 4.0 | 1 | 5.72 |
| CHEMBL27767 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281947 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL281947 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL488 | AMINOGLUTETHIMIDE | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL27767 | — | IC50 | = | 777000.0 | nM | - |