Assay Detail
Binding
CHEMBL645594
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against aldose reductase enzyme
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL1900) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Substituted pyrrol-1-ylacetic acids that combine aldose reductase enzyme inhibitory activity and ability to prevent the nonenzymatic irreversible modification of proteins from monosaccharides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.86 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10372 | ZOPOLRESTAT | 2.0 | 1 | 8.51 |
| CHEMBL56337 | EPALRESTAT | 4.0 | 1 | 8.00 |
| CHEMBL84446 | FIDARESTAT | 2.0 | 1 | 7.46 |
| CHEMBL436 | TOLRESTAT | 4.0 | 1 | 7.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10372 | ZOPOLRESTAT | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL56337 | EPALRESTAT | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL84446 | FIDARESTAT | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL436 | TOLRESTAT | IC50 | = | 35.0 | nM | 7.46 |