Assay Detail
Functional
CHEMBL645608
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Alpha-2 adrenergic receptor antagonistic activity in human blood platelets.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Blood |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Medetomidine analogs as alpha 2-adrenergic ligands. 2. Design, synthesis, and biological activity of conformationally restricted naphthalene derivatives of medetomidine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.80 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL77921 | MEDETOMIDINE | 3.0 | 1 | 5.54 |
| CHEMBL105328 | — | — | 1 | 4.84 |
| CHEMBL420652 | — | — | 1 | 4.01 |
| CHEMBL322844 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL77921 | MEDETOMIDINE | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL105328 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL420652 | — | IC50 | = | 97700.0 | nM | 4.01 |
| CHEMBL322844 | — | IC50 | = | 215400.0 | nM | - |