Assay Detail
Binding
CHEMBL645610
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Compound was evaluated for Adrenergic activity against Alpha-2 adrenergic receptor in human platelets
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and alpha-adrenergic activities of 2- and 4-substituted imidazoline and imidazole analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 10.14 | 10.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL553231 | — | — | 1 | 10.85 |
| CHEMBL557985 | — | — | 1 | 10.80 |
| CHEMBL537830 | — | — | 1 | 10.47 |
| CHEMBL538801 | — | — | 1 | 9.92 |
| CHEMBL554581 | — | — | 1 | 9.59 |
| CHEMBL164540 | — | — | 1 | 9.21 |
| CHEMBL1706 | NAPHAZOLINE HYDROCHLORIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL553231 | — | IC50 | = | 0.014 | nM | 10.85 |
| CHEMBL557985 | — | IC50 | = | 0.016 | nM | 10.80 |
| CHEMBL537830 | — | IC50 | = | 0.034 | nM | 10.47 |
| CHEMBL538801 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL554581 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL164540 | — | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL1706 | NAPHAZOLINE HYDROCHLORIDE | IC50 | = | 0.0011 | nM | - |