Assay Detail
Binding
CHEMBL645676
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Inhibition of recombinant human E-type adenylate deaminase
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
AMP deaminase inhibitors. 5. Design, synthesis, and SAR of a highly potent inhibitor series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 6.43 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL346040 | — | — | 1 | 8.70 |
| CHEMBL157468 | — | — | 1 | 8.05 |
| CHEMBL157949 | — | — | 1 | 7.82 |
| CHEMBL346360 | — | — | 1 | 7.70 |
| CHEMBL160174 | — | — | 1 | 7.52 |
| CHEMBL157743 | — | — | 1 | 7.40 |
| CHEMBL280097 | — | — | 1 | 7.30 |
| CHEMBL158023 | — | — | 1 | 7.05 |
| CHEMBL157426 | — | — | 1 | 6.66 |
| CHEMBL158136 | — | — | 1 | 6.52 |
| CHEMBL350676 | — | — | 1 | 6.52 |
| CHEMBL35929 | — | — | 1 | 6.39 |
| CHEMBL35524 | — | — | 1 | 6.30 |
| CHEMBL154259 | — | — | 1 | 6.30 |
| CHEMBL156217 | — | — | 1 | 6.02 |
| CHEMBL157669 | — | — | 1 | 6.00 |
| CHEMBL156990 | — | — | 1 | 5.89 |
| CHEMBL157951 | — | — | 1 | 5.75 |
| CHEMBL157800 | — | — | 1 | 5.64 |
| CHEMBL160384 | — | — | 1 | 5.62 |
| CHEMBL284483 | COFORMYCIN | 2.0 | 1 | 5.52 |
| CHEMBL347030 | — | — | 1 | 5.42 |
| CHEMBL157723 | — | — | 1 | 5.30 |
| CHEMBL348608 | — | — | 1 | 4.85 |
| CHEMBL156756 | — | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL346040 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL157468 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL157949 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL346360 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL160174 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL157743 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL280097 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL158023 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL157426 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL158136 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL350676 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL35929 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL35524 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL154259 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL156217 | — | Ki | = | 960.0 | nM | 6.02 |
| CHEMBL157669 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL156990 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL157951 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL157800 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL160384 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL284483 | COFORMYCIN | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL347030 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL157723 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL348608 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL156756 | — | Ki | = | 35000.0 | nM | 4.46 |