Assay Detail
Binding
CHEMBL645679
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Inhibitory activity against porcine heart Adenylate deaminase (AMPDA)
62
Total Activities
62
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
AMP deaminase inhibitors. 3. SAR of 3-(carboxyarylalkyl)coformycin aglycon analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 62 | 5.34 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39554 | — | — | 1 | 7.22 |
| CHEMBL430742 | — | — | 1 | 7.16 |
| CHEMBL37071 | — | — | 1 | 7.10 |
| CHEMBL289788 | — | — | 1 | 7.10 |
| CHEMBL35488 | — | — | 1 | 7.00 |
| CHEMBL36750 | — | — | 1 | 6.80 |
| CHEMBL288184 | — | — | 1 | 6.75 |
| CHEMBL288157 | — | — | 1 | 6.72 |
| CHEMBL37296 | — | — | 1 | 6.72 |
| CHEMBL36636 | — | — | 1 | 6.66 |
| CHEMBL35730 | — | — | 1 | 6.54 |
| CHEMBL284779 | — | — | 1 | 6.46 |
| CHEMBL37305 | — | — | 1 | 6.32 |
| CHEMBL35524 | — | — | 1 | 6.29 |
| CHEMBL288013 | — | — | 1 | 6.24 |
| CHEMBL35724 | — | — | 1 | 5.82 |
| CHEMBL35777 | — | — | 1 | 5.80 |
| CHEMBL290619 | — | — | 1 | 5.66 |
| CHEMBL38038 | — | — | 1 | 5.57 |
| CHEMBL37559 | — | — | 1 | 5.38 |
| CHEMBL39391 | — | — | 1 | 5.35 |
| CHEMBL37910 | — | — | 1 | 5.32 |
| CHEMBL37750 | — | — | 1 | 5.28 |
| CHEMBL39389 | — | — | 1 | 5.20 |
| CHEMBL36790 | — | — | 1 | 5.18 |
| CHEMBL288909 | — | — | 1 | 5.09 |
| CHEMBL37181 | — | — | 1 | 5.08 |
| CHEMBL39694 | — | — | 1 | 5.05 |
| CHEMBL37494 | — | — | 1 | 5.02 |
| CHEMBL37408 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39554 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL430742 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL289788 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL37071 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL35488 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL36750 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL288184 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL288157 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL37296 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL36636 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL35730 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL284779 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL37305 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL35524 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL288013 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL35724 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL35777 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL290619 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL38038 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL37559 | — | Ki | = | 4200.0 | nM | 5.38 |
| CHEMBL39391 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL37910 | — | Ki | = | 4800.0 | nM | 5.32 |
| CHEMBL37750 | — | Ki | = | 5200.0 | nM | 5.28 |
| CHEMBL39389 | — | Ki | = | 6300.0 | nM | 5.20 |
| CHEMBL36790 | — | Ki | = | 6600.0 | nM | 5.18 |
| CHEMBL288909 | — | Ki | = | 8100.0 | nM | 5.09 |
| CHEMBL37181 | — | Ki | = | 8300.0 | nM | 5.08 |
| CHEMBL39694 | — | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL37494 | — | Ki | = | 9500.0 | nM | 5.02 |
| CHEMBL37408 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL37074 | — | Ki | = | 11200.0 | nM | 4.95 |
| CHEMBL288819 | — | Ki | = | 11800.0 | nM | 4.93 |
| CHEMBL34859 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL39430 | — | Ki | = | 12500.0 | nM | 4.90 |
| CHEMBL418056 | — | Ki | = | 13300.0 | nM | 4.88 |
| CHEMBL289027 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL37027 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL37090 | — | Ki | = | 15900.0 | nM | 4.80 |
| CHEMBL38128 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL448777 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL287365 | — | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL37183 | — | Ki | = | 22000.0 | nM | 4.66 |
| CHEMBL431512 | — | Ki | = | 23500.0 | nM | 4.63 |
| CHEMBL39924 | — | Ki | = | 24000.0 | nM | 4.62 |
| CHEMBL290381 | — | Ki | = | 24300.0 | nM | 4.61 |
| CHEMBL288414 | — | Ki | = | 31300.0 | nM | 4.50 |
| CHEMBL36860 | — | Ki | = | 31800.0 | nM | 4.50 |
| CHEMBL290030 | — | Ki | = | 32700.0 | nM | 4.49 |
| CHEMBL288607 | — | Ki | = | 37900.0 | nM | 4.42 |
| CHEMBL290111 | — | Ki | = | 38000.0 | nM | 4.42 |