Assay Detail
Binding
CHEMBL645784
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Affinity for human Adenosine A3 receptor expressed in CHO cell
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 7.76 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL139417 | — | — | 1 | 8.89 |
| CHEMBL431733 | NAMODENOSON | 3.0 | 1 | 8.85 |
| CHEMBL369744 | — | — | 1 | 8.82 |
| CHEMBL119709 | IB-MECA | — | 1 | 8.74 |
| CHEMBL307199 | — | — | 1 | 8.74 |
| CHEMBL342873 | — | — | 1 | 8.72 |
| CHEMBL133387 | — | — | 1 | 8.68 |
| CHEMBL345076 | — | — | 1 | 8.47 |
| CHEMBL66393 | — | — | 1 | 8.24 |
| CHEMBL139000 | (R)-PIA | — | 1 | 8.06 |
| CHEMBL138781 | — | — | 1 | 8.04 |
| CHEMBL344187 | — | — | 1 | 7.53 |
| CHEMBL464859 | NECA | — | 1 | 7.46 |
| CHEMBL284969 | — | — | 1 | 7.42 |
| CHEMBL420705 | (S)-PIA | — | 1 | 7.17 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 7.14 |
| CHEMBL285819 | — | — | 1 | 7.06 |
| CHEMBL290077 | — | — | 1 | 7.00 |
| CHEMBL141792 | — | — | 1 | 6.94 |
| CHEMBL337602 | — | — | 1 | 6.45 |
| CHEMBL342926 | — | — | 1 | 6.24 |
| CHEMBL138746 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL139417 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL431733 | NAMODENOSON | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL369744 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL119709 | IB-MECA | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL307199 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL342873 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL133387 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL345076 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL66393 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL139000 | (R)-PIA | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL138781 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL344187 | — | Ki | = | 29.3 | nM | 7.53 |
| CHEMBL464859 | NECA | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL284969 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL420705 | (S)-PIA | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL285819 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL290077 | — | Ki | = | 99.0 | nM | 7.00 |
| CHEMBL141792 | — | Ki | = | 114.0 | nM | 6.94 |
| CHEMBL337602 | — | Ki | = | 353.0 | nM | 6.45 |
| CHEMBL342926 | — | Ki | = | 572.0 | nM | 6.24 |
| CHEMBL138746 | — | Ki | = | 816.0 | nM | 6.09 |