Assay Detail
Binding
CHEMBL645934
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel acyl-CoA:cholesterol acyltransferase inhibitors. Synthesis and biological activity of 3-quinolylurea derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.27 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64976 | — | — | 1 | 8.24 |
| CHEMBL62332 | — | — | 1 | 8.05 |
| CHEMBL62063 | — | — | 1 | 8.04 |
| CHEMBL63019 | — | — | 1 | 8.03 |
| CHEMBL63674 | — | — | 1 | 7.92 |
| CHEMBL62876 | — | — | 1 | 7.92 |
| CHEMBL65108 | — | — | 1 | 7.85 |
| CHEMBL63408 | — | — | 1 | 7.85 |
| CHEMBL304930 | — | — | 1 | 7.82 |
| CHEMBL62894 | — | — | 1 | 7.78 |
| CHEMBL62464 | — | — | 1 | 7.67 |
| CHEMBL413330 | — | — | 1 | 7.66 |
| CHEMBL291356 | — | — | 1 | 7.62 |
| CHEMBL65602 | — | — | 1 | 7.55 |
| CHEMBL63593 | — | — | 1 | 7.54 |
| CHEMBL303527 | — | — | 1 | 7.04 |
| CHEMBL278042 | — | — | 1 | 6.92 |
| CHEMBL65347 | — | — | 1 | 6.90 |
| CHEMBL433299 | — | — | 1 | 6.83 |
| CHEMBL67373 | — | — | 1 | 6.80 |
| CHEMBL67782 | — | — | 1 | 6.67 |
| CHEMBL62463 | — | — | 1 | 6.27 |
| CHEMBL292544 | — | — | 1 | 6.10 |
| CHEMBL303281 | — | — | 1 | 6.06 |
| CHEMBL63878 | — | — | 1 | 6.03 |
| CHEMBL302238 | — | — | 1 | 5.89 |
| CHEMBL305124 | — | — | 1 | - |
| CHEMBL65368 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64976 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL62332 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL62063 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL63019 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL63674 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL62876 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL65108 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL63408 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL304930 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL62894 | — | IC50 | = | 16.8 | nM | 7.78 |
| CHEMBL62464 | — | IC50 | = | 21.2 | nM | 7.67 |
| CHEMBL413330 | — | IC50 | = | 21.7 | nM | 7.66 |
| CHEMBL291356 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL65602 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL63593 | — | IC50 | = | 28.7 | nM | 7.54 |
| CHEMBL303527 | — | IC50 | = | 90.6 | nM | 7.04 |
| CHEMBL278042 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL65347 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL433299 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL67373 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL67782 | — | IC50 | = | 215.0 | nM | 6.67 |
| CHEMBL62463 | — | IC50 | = | 534.0 | nM | 6.27 |
| CHEMBL292544 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL303281 | — | IC50 | = | 864.0 | nM | 6.06 |
| CHEMBL63878 | — | IC50 | = | 929.0 | nM | 6.03 |
| CHEMBL302238 | — | IC50 | = | 1296.0 | nM | 5.89 |
| CHEMBL305124 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL65368 | — | IC50 | > | 1000.0 | nM | - |