Assay Detail
Functional
CHEMBL645945
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Cytotoxic effect on v-abl transformed murine ANN-1 cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | ANN-1 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Structural studies on bioactive compounds. 23. Synthesis of polyhydroxylated 2-phenylbenzothiazoles and a comparison of their cytotoxicities and pharmacological properties with genistein and quercetin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.79 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL47966 | — | — | 1 | 5.70 |
| CHEMBL411 | DIETHYLSTILBESTROL | 4.0 | 1 | 5.52 |
| CHEMBL295539 | — | — | 1 | 5.26 |
| CHEMBL44 | GENISTEIN | 2.0 | 1 | 5.10 |
| CHEMBL48033 | — | — | 1 | 5.05 |
| CHEMBL44227 | — | — | 1 | 4.87 |
| CHEMBL44326 | — | — | 1 | 4.77 |
| CHEMBL45564 | — | — | 1 | 4.67 |
| CHEMBL43722 | — | — | 1 | 4.59 |
| CHEMBL46786 | — | — | 1 | 4.50 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 4.49 |
| CHEMBL48085 | — | — | 1 | 4.23 |
| CHEMBL47361 | — | — | 1 | 4.15 |
| CHEMBL47875 | — | — | 1 | 4.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL47966 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL411 | DIETHYLSTILBESTROL | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL295539 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL44 | GENISTEIN | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL48033 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL44227 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL44326 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL45564 | — | IC50 | = | 21500.0 | nM | 4.67 |
| CHEMBL43722 | — | IC50 | = | 25500.0 | nM | 4.59 |
| CHEMBL46786 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL50 | QUERCETIN | IC50 | = | 32500.0 | nM | 4.49 |
| CHEMBL48085 | — | IC50 | = | 58500.0 | nM | 4.23 |
| CHEMBL47361 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL47875 | — | IC50 | = | 77000.0 | nM | 4.11 |