Assay Detail
Functional
CHEMBL645951
Review assay metadata, readout intent, target linkage, and publication context from the same page.
AP-1 suppression activity using two months old DMSO stock
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Dual specificity mitogen-activated protein kinase kinase; MEK1/2 (CHEMBL2111289) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.30 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34704 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34704 | — | IC50 | = | 500.0 | nM | 6.30 |