Assay Detail
Binding
CHEMBL645970
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Binding affinity for human adenosine A2B receptor using [3H]ZM-241385 in CHO cell membranes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Preparation, properties, reactions, and adenosine receptor affinities of sulfophenylxanthine nitrophenyl esters: toward the development of sulfonic acid prodrugs with peroral bioavailability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.67 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274855 | — | — | 1 | 8.33 |
| CHEMBL8789 | — | — | 1 | 7.93 |
| CHEMBL275987 | — | — | 1 | 7.27 |
| CHEMBL268617 | — | — | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274855 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL8789 | — | Ki | = | 11.8 | nM | 7.93 |
| CHEMBL275987 | — | Ki | = | 53.4 | nM | 7.27 |
| CHEMBL268617 | — | Ki | = | 70.0 | nM | 7.16 |