Assay Detail
Binding
CHEMBL645993
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Binding affinity to the adrenergic receptor alpha-1D of rat aorta
81
Total Activities
81
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Aorta |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Synthesis, screening, and molecular modeling of new potent and selective antagonists at the alpha 1d adrenergic receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 81 | 8.18 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301224 | — | — | 1 | 9.96 |
| CHEMBL56438 | — | — | 1 | 9.89 |
| CHEMBL556313 | — | — | 1 | 9.85 |
| CHEMBL293539 | — | — | 1 | 9.74 |
| CHEMBL57868 | — | — | 1 | 9.70 |
| CHEMBL55654 | — | — | 1 | 9.43 |
| CHEMBL57859 | — | — | 1 | 9.43 |
| CHEMBL300152 | — | — | 1 | 9.39 |
| CHEMBL299454 | — | — | 1 | 9.27 |
| CHEMBL59262 | — | — | 1 | 9.17 |
| CHEMBL299253 | — | — | 1 | 9.08 |
| CHEMBL57593 | — | — | 1 | 9.08 |
| CHEMBL299691 | — | — | 1 | 9.04 |
| CHEMBL299022 | — | — | 1 | 9.03 |
| CHEMBL56292 | — | — | 1 | 8.96 |
| CHEMBL57317 | — | — | 1 | 8.91 |
| CHEMBL56804 | — | — | 1 | 8.87 |
| CHEMBL298595 | — | — | 1 | 8.86 |
| CHEMBL292366 | — | — | 1 | 8.85 |
| CHEMBL440118 | — | — | 1 | 8.82 |
| CHEMBL56869 | — | — | 1 | 8.80 |
| CHEMBL55319 | — | — | 1 | 8.76 |
| CHEMBL57364 | — | — | 1 | 8.70 |
| CHEMBL291908 | — | — | 1 | 8.67 |
| CHEMBL293111 | — | — | 1 | 8.66 |
| CHEMBL58476 | — | — | 1 | 8.62 |
| CHEMBL55882 | — | — | 1 | 8.58 |
| CHEMBL431943 | — | — | 1 | 8.54 |
| CHEMBL60583 | — | — | 1 | 8.54 |
| CHEMBL59149 | — | — | 1 | 8.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301224 | — | Ki | = | 0.11 | nM | 9.96 |
| CHEMBL56438 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL556313 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL293539 | — | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL57868 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL55654 | — | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL57859 | — | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL300152 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL299454 | — | Ki | = | 0.54 | nM | 9.27 |
| CHEMBL59262 | — | Ki | = | 0.67 | nM | 9.17 |
| CHEMBL299253 | — | Ki | = | 0.84 | nM | 9.08 |
| CHEMBL57593 | — | Ki | = | 0.83 | nM | 9.08 |
| CHEMBL299691 | — | Ki | = | 0.91 | nM | 9.04 |
| CHEMBL299022 | — | Ki | = | 0.93 | nM | 9.03 |
| CHEMBL56292 | — | Ki | = | 1.11 | nM | 8.96 |
| CHEMBL57317 | — | Ki | = | 1.23 | nM | 8.91 |
| CHEMBL56804 | — | Ki | = | 1.34 | nM | 8.87 |
| CHEMBL298595 | — | Ki | = | 1.38 | nM | 8.86 |
| CHEMBL292366 | — | Ki | = | 1.43 | nM | 8.85 |
| CHEMBL440118 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL56869 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL55319 | — | Ki | = | 1.72 | nM | 8.76 |
| CHEMBL57364 | — | Ki | = | 2.02 | nM | 8.70 |
| CHEMBL291908 | — | Ki | = | 2.16 | nM | 8.67 |
| CHEMBL293111 | — | Ki | = | 2.21 | nM | 8.66 |
| CHEMBL58476 | — | Ki | = | 2.38 | nM | 8.62 |
| CHEMBL55882 | — | Ki | = | 2.65 | nM | 8.58 |
| CHEMBL431943 | — | Ki | = | 2.88 | nM | 8.54 |
| CHEMBL60583 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL59149 | — | Ki | = | 2.91 | nM | 8.54 |
| CHEMBL56620 | — | Ki | = | 3.11 | nM | 8.51 |
| CHEMBL57540 | — | Ki | = | 3.15 | nM | 8.50 |
| CHEMBL294235 | — | Ki | = | 3.25 | nM | 8.49 |
| CHEMBL292686 | — | Ki | = | 3.66 | nM | 8.44 |
| CHEMBL56899 | — | Ki | = | 3.72 | nM | 8.43 |
| CHEMBL293980 | — | Ki | = | 3.89 | nM | 8.41 |
| CHEMBL293968 | — | Ki | = | 4.32 | nM | 8.37 |
| CHEMBL56805 | — | Ki | = | 5.25 | nM | 8.28 |
| CHEMBL56150 | — | Ki | = | 5.38 | nM | 8.27 |
| CHEMBL57882 | — | Ki | = | 7.56 | nM | 8.12 |
| CHEMBL294646 | — | Ki | = | 7.78 | nM | 8.11 |
| CHEMBL13647 | BMY-7378 | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL293734 | — | Ki | = | 8.74 | nM | 8.06 |
| CHEMBL431354 | — | Ki | = | 10.14 | nM | 7.99 |
| CHEMBL57999 | — | Ki | = | 12.66 | nM | 7.90 |
| CHEMBL58930 | — | Ki | = | 14.79 | nM | 7.83 |
| CHEMBL58384 | — | Ki | = | 15.29 | nM | 7.82 |
| CHEMBL55647 | — | Ki | = | 15.34 | nM | 7.81 |
| CHEMBL55790 | — | Ki | = | 16.38 | nM | 7.79 |
| CHEMBL59315 | — | Ki | = | 16.08 | nM | 7.79 |