Assay Detail
Binding
CHEMBL645994
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | LTK |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Structure-activity studies for a novel series of bicyclic substituted hexahydrobenz[e]isoindole alpha1A adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 43 | 8.66 | 9.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58956 | — | — | 1 | 9.68 |
| CHEMBL62028 | — | — | 1 | 9.62 |
| CHEMBL61598 | — | — | 1 | 9.39 |
| CHEMBL445071 | — | — | 1 | 9.28 |
| CHEMBL60471 | — | — | 1 | 9.24 |
| CHEMBL61491 | — | — | 1 | 9.21 |
| CHEMBL61483 | — | — | 1 | 9.18 |
| CHEMBL293695 | — | — | 1 | 9.17 |
| CHEMBL440865 | — | — | 1 | 9.16 |
| CHEMBL60721 | — | — | 1 | 9.15 |
| CHEMBL60510 | — | — | 1 | 9.14 |
| CHEMBL369154 | — | — | 1 | 9.11 |
| CHEMBL62033 | — | — | 1 | 9.11 |
| CHEMBL431720 | — | — | 1 | 9.05 |
| CHEMBL291839 | — | — | 1 | 9.04 |
| CHEMBL2115086 | — | — | 1 | 9.04 |
| CHEMBL292881 | — | — | 1 | 9.00 |
| CHEMBL61225 | — | — | 1 | 8.95 |
| CHEMBL62110 | — | — | 1 | 8.95 |
| CHEMBL302203 | — | — | 1 | 8.94 |
| CHEMBL304215 | — | — | 1 | 8.92 |
| CHEMBL293236 | — | — | 1 | 8.86 |
| CHEMBL291303 | — | — | 1 | 8.85 |
| CHEMBL294027 | — | — | 1 | 8.84 |
| CHEMBL291528 | — | — | 1 | 8.82 |
| CHEMBL294098 | — | — | 1 | 8.78 |
| CHEMBL432147 | — | — | 1 | 8.75 |
| CHEMBL60722 | — | — | 1 | 8.70 |
| CHEMBL299907 | — | — | 1 | 8.60 |
| CHEMBL62109 | — | — | 1 | 8.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58956 | — | Ki | = | 0.21 | nM | 9.68 |
| CHEMBL62028 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL61598 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL445071 | — | Ki | = | 0.52 | nM | 9.28 |
| CHEMBL60471 | — | Ki | = | 0.58 | nM | 9.24 |
| CHEMBL61491 | — | Ki | = | 0.62 | nM | 9.21 |
| CHEMBL61483 | — | Ki | = | 0.66 | nM | 9.18 |
| CHEMBL293695 | — | Ki | = | 0.68 | nM | 9.17 |
| CHEMBL440865 | — | Ki | = | 0.69 | nM | 9.16 |
| CHEMBL60721 | — | Ki | = | 0.71 | nM | 9.15 |
| CHEMBL60510 | — | Ki | = | 0.73 | nM | 9.14 |
| CHEMBL62033 | — | Ki | = | 0.77 | nM | 9.11 |
| CHEMBL369154 | — | Ki | = | 0.77 | nM | 9.11 |
| CHEMBL431720 | — | Ki | = | 0.89 | nM | 9.05 |
| CHEMBL2115086 | — | Ki | = | 0.92 | nM | 9.04 |
| CHEMBL291839 | — | Ki | = | 0.92 | nM | 9.04 |
| CHEMBL292881 | — | Ki | = | 1.01 | nM | 9.00 |
| CHEMBL61225 | — | Ki | = | 1.13 | nM | 8.95 |
| CHEMBL62110 | — | Ki | = | 1.13 | nM | 8.95 |
| CHEMBL302203 | — | Ki | = | 1.15 | nM | 8.94 |
| CHEMBL304215 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL293236 | — | Ki | = | 1.38 | nM | 8.86 |
| CHEMBL291303 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL294027 | — | Ki | = | 1.45 | nM | 8.84 |
| CHEMBL291528 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL294098 | — | Ki | = | 1.67 | nM | 8.78 |
| CHEMBL432147 | — | Ki | = | 1.78 | nM | 8.75 |
| CHEMBL60722 | — | Ki | = | 1.99 | nM | 8.70 |
| CHEMBL299907 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL62109 | — | Ki | = | 2.71 | nM | 8.57 |
| CHEMBL291769 | — | Ki | = | 2.86 | nM | 8.54 |
| CHEMBL291588 | — | Ki | = | 2.87 | nM | 8.54 |
| CHEMBL58862 | — | Ki | = | 3.71 | nM | 8.43 |
| CHEMBL290387 | — | Ki | = | 3.83 | nM | 8.42 |
| CHEMBL58105 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL62206 | — | Ki | = | 5.49 | nM | 8.26 |
| CHEMBL445325 | — | Ki | = | 7.79 | nM | 8.11 |
| CHEMBL58612 | — | Ki | = | 32.65 | nM | 7.49 |
| CHEMBL291305 | — | Ki | = | 58.4 | nM | 7.23 |
| CHEMBL303988 | — | Ki | = | 71.97 | nM | 7.14 |
| CHEMBL59575 | — | Ki | = | 83.4 | nM | 7.08 |
| CHEMBL58585 | — | Ki | = | 168.2 | nM | 6.77 |
| CHEMBL302192 | — | Ki | = | 189.0 | nM | 6.72 |