Assay Detail
Binding
CHEMBL646001
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
4-Amino-2-[4-[1-(benzyloxycarbonyl)-2(S)- [[(1,1-dimethylethyl)amino]carbonyl]-piperazinyl]-6, 7-dimethoxyquinazoline (L-765,314): a potent and selective alpha1b adrenergic receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.55 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 9.52 |
| CHEMBL13647 | BMY-7378 | — | 1 | 8.62 |
| CHEMBL611 | TERAZOSIN | 4.0 | 1 | 8.47 |
| CHEMBL19476 | L-765314 | — | 1 | 7.30 |
| CHEMBL19826 | — | — | 1 | 7.11 |
| CHEMBL19376 | — | — | 1 | 6.20 |
| CHEMBL2079655 | — | — | 1 | 5.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2 | PRAZOSIN | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL13647 | BMY-7378 | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL611 | TERAZOSIN | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL19476 | L-765314 | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL19826 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL19376 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL2079655 | — | Ki | = | 2250.0 | nM | 5.65 |