Assay Detail
Binding
CHEMBL646002
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
42
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | LTK |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity studies for a novel series of tricyclic substituted hexahydrobenz[e]isoindole alpha(1A) adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia (BPH).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 42 | 8.72 | 9.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL291073 | — | — | 1 | 9.57 |
| CHEMBL287965 | — | — | 1 | 9.55 |
| CHEMBL41444 | — | — | 1 | 9.51 |
| CHEMBL40754 | — | — | 1 | 9.43 |
| CHEMBL289361 | — | — | 2 | 9.43 |
| CHEMBL290388 | — | — | 1 | 9.29 |
| CHEMBL40650 | — | — | 1 | 9.29 |
| CHEMBL41155 | — | — | 1 | 9.23 |
| CHEMBL290519 | — | — | 1 | 9.20 |
| CHEMBL417890 | — | — | 1 | 9.17 |
| CHEMBL291262 | — | — | 1 | 9.16 |
| CHEMBL40780 | — | — | 1 | 9.13 |
| CHEMBL288809 | — | — | 1 | 9.13 |
| CHEMBL39037 | — | — | 1 | 9.06 |
| CHEMBL2112073 | — | — | 2 | 9.03 |
| CHEMBL40310 | — | — | 1 | 8.98 |
| CHEMBL41344 | — | — | 1 | 8.97 |
| CHEMBL41234 | — | — | 1 | 8.96 |
| CHEMBL441032 | — | — | 1 | 8.96 |
| CHEMBL291154 | — | — | 1 | 8.88 |
| CHEMBL40819 | — | — | 1 | 8.88 |
| CHEMBL287928 | — | — | 1 | 8.85 |
| CHEMBL288530 | — | — | 1 | 8.69 |
| CHEMBL288678 | — | — | 1 | 8.68 |
| CHEMBL289627 | — | — | 1 | 8.68 |
| CHEMBL297218 | — | — | 1 | 8.64 |
| CHEMBL43573 | — | — | 1 | 8.55 |
| CHEMBL290243 | — | — | 1 | 8.48 |
| CHEMBL40896 | — | — | 1 | 8.43 |
| CHEMBL289437 | — | — | 1 | 8.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL291073 | — | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL287965 | — | Ki | = | 0.28 | nM | 9.55 |
| CHEMBL41444 | — | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL40754 | — | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL289361 | — | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL290388 | — | Ki | = | 0.51 | nM | 9.29 |
| CHEMBL40650 | — | Ki | = | 0.51 | nM | 9.29 |
| CHEMBL41155 | — | Ki | = | 0.59 | nM | 9.23 |
| CHEMBL289361 | — | Ki | = | 0.63 | nM | 9.20 |
| CHEMBL290519 | — | Ki | = | 0.63 | nM | 9.20 |
| CHEMBL417890 | — | Ki | = | 0.68 | nM | 9.17 |
| CHEMBL291262 | — | Ki | = | 0.69 | nM | 9.16 |
| CHEMBL288809 | — | Ki | = | 0.74 | nM | 9.13 |
| CHEMBL40780 | — | Ki | = | 0.74 | nM | 9.13 |
| CHEMBL39037 | — | Ki | = | 0.88 | nM | 9.06 |
| CHEMBL2112073 | — | Ki | = | 0.94 | nM | 9.03 |
| CHEMBL40310 | — | Ki | = | 1.04 | nM | 8.98 |
| CHEMBL41344 | — | Ki | = | 1.07 | nM | 8.97 |
| CHEMBL441032 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL41234 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL40819 | — | Ki | = | 1.31 | nM | 8.88 |
| CHEMBL291154 | — | Ki | = | 1.32 | nM | 8.88 |
| CHEMBL287928 | — | Ki | = | 1.41 | nM | 8.85 |
| CHEMBL288530 | — | Ki | = | 2.06 | nM | 8.69 |
| CHEMBL289627 | — | Ki | = | 2.08 | nM | 8.68 |
| CHEMBL288678 | — | Ki | = | 2.08 | nM | 8.68 |
| CHEMBL297218 | — | Ki | = | 2.31 | nM | 8.64 |
| CHEMBL43573 | — | Ki | = | 2.84 | nM | 8.55 |
| CHEMBL290243 | — | Ki | = | 3.28 | nM | 8.48 |
| CHEMBL40896 | — | Ki | = | 3.74 | nM | 8.43 |
| CHEMBL289437 | — | Ki | = | 4.16 | nM | 8.38 |
| CHEMBL289758 | — | Ki | = | 4.77 | nM | 8.32 |
| CHEMBL43921 | — | Ki | = | 5.76 | nM | 8.24 |
| CHEMBL2112073 | — | Ki | = | 6.28 | nM | 8.20 |
| CHEMBL289166 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL43234 | — | Ki | = | 6.84 | nM | 8.16 |
| CHEMBL40564 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL434591 | — | Ki | = | 8.67 | nM | 8.06 |
| CHEMBL43909 | — | Ki | = | 19.8 | nM | 7.70 |
| CHEMBL41396 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL41332 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL296711 | — | Ki | = | 160.0 | nM | 6.80 |