Assay Detail
Binding
CHEMBL646003
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Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.02 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL324090 | ABANOQUIL | 2.0 | 1 | 10.52 |
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 9.10 |
| CHEMBL25554 | — | — | 1 | 8.92 |
| CHEMBL709 | ALFUZOSIN | 4.0 | 1 | 8.46 |
| CHEMBL611 | TERAZOSIN | 4.0 | 1 | 7.46 |
| CHEMBL10347 | RAUWOLSCINE | — | 1 | 7.46 |
| CHEMBL15245 | YOHIMBINE | 3.0 | 1 | 7.28 |
| CHEMBL420060 | — | — | 1 | 6.73 |
| CHEMBL279516 | INDORAMIN | 2.0 | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL324090 | ABANOQUIL | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL2 | PRAZOSIN | Ki | = | 0.79 | nM | 9.10 |
| CHEMBL25554 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL709 | ALFUZOSIN | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL611 | TERAZOSIN | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL10347 | RAUWOLSCINE | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL15245 | YOHIMBINE | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL420060 | — | Ki | = | 186.0 | nM | 6.73 |
| CHEMBL279516 | INDORAMIN | Ki | = | 611.0 | nM | 6.21 |