Assay Detail
Functional
CHEMBL646005
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic activity against Alpha-1D adrenergic receptor determined using phenylephrine challenge in rat aorta isolated tissues.
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Aorta |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 1 | 6.20 | 6.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL326702 | — | — | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL326702 | — | Kd | = | 630.96 | nM | 6.20 |