Assay Detail
Binding
CHEMBL646015
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Binding affinity towards rat Alpha-1A adrenergic receptor
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Two novel and potent 3-[(o-methoxyphenyl)piperazinylethyl]-5-phenylthien.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.48 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13735 | — | — | 1 | 9.28 |
| CHEMBL13903 | — | — | 1 | 9.24 |
| CHEMBL13754 | — | — | 1 | 8.71 |
| CHEMBL268758 | A-119637 | — | 1 | 8.61 |
| CHEMBL14213 | — | — | 1 | 8.58 |
| CHEMBL13856 | A-123189 | — | 1 | 8.46 |
| CHEMBL14199 | — | — | 1 | 8.02 |
| CHEMBL13647 | BMY-7378 | — | 1 | 6.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13735 | — | Ki | = | 0.523 | nM | 9.28 |
| CHEMBL13903 | — | Ki | = | 0.578 | nM | 9.24 |
| CHEMBL13754 | — | Ki | = | 1.97 | nM | 8.71 |
| CHEMBL268758 | A-119637 | Ki | = | 2.43 | nM | 8.61 |
| CHEMBL14213 | — | Ki | = | 2.62 | nM | 8.58 |
| CHEMBL13856 | A-123189 | Ki | = | 3.47 | nM | 8.46 |
| CHEMBL14199 | — | Ki | = | 9.58 | nM | 8.02 |
| CHEMBL13647 | BMY-7378 | Ki | = | 112.0 | nM | 6.95 |