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Assay Detail

CHEMBL646028

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity towards angiotensin II AT2 receptor subtype was determined using rat isolated adrenal cortical microsomes
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Type-2 angiotensin II receptor (CHEMBL257)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

A novel series of selective, non-peptide inhibitors of angiotensin II binding to the AT2 site.
VanAtten MK, Ensinger CL, Chiu AT, McCall DE, Nguyen TT, Wexler RR, Timmermans PB.
J Med Chem (1993) 36 : 3985 -3992
PubMed 8258820 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 8.00 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL294558 1 8.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL294558 IC50 = 10.0 nM 8.00