Assay Detail
Binding
CHEMBL646054
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Concentration required for the in vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in liver microsomes isolated from cholesterol-fed rats
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Inhibitors of acyl-CoA: Cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 12. Syntheses and biological activity of structurally novel tetrazole amides
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.43 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99056 | — | — | 1 | 7.10 |
| CHEMBL317244 | — | — | 1 | 7.10 |
| CHEMBL22373 | CL-976 | — | 1 | 6.96 |
| CHEMBL101629 | — | — | 1 | 6.92 |
| CHEMBL100936 | — | — | 1 | 6.85 |
| CHEMBL318373 | — | — | 1 | 6.75 |
| CHEMBL98716 | — | — | 1 | 6.72 |
| CHEMBL101601 | — | — | 1 | 6.62 |
| CHEMBL101883 | — | — | 1 | 6.60 |
| CHEMBL100697 | — | — | 1 | 6.51 |
| CHEMBL101278 | — | — | 1 | 6.46 |
| CHEMBL98742 | — | — | 1 | 6.46 |
| CHEMBL316471 | — | — | 1 | 6.42 |
| CHEMBL99029 | — | — | 1 | 6.42 |
| CHEMBL97926 | — | — | 1 | 6.36 |
| CHEMBL100993 | — | — | 1 | 6.34 |
| CHEMBL101937 | — | — | 1 | 6.31 |
| CHEMBL100533 | — | — | 1 | 6.29 |
| CHEMBL98598 | — | — | 1 | 6.27 |
| CHEMBL101865 | — | — | 1 | 6.22 |
| CHEMBL101977 | — | — | 1 | 6.19 |
| CHEMBL321102 | — | — | 1 | 6.09 |
| CHEMBL98365 | — | — | 1 | 6.07 |
| CHEMBL98612 | — | — | 1 | 5.77 |
| CHEMBL45333 | — | — | 1 | 5.03 |
| CHEMBL317503 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99056 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL317244 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL22373 | CL-976 | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL101629 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL100936 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL318373 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL98716 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL101601 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL101883 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL100697 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL101278 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL98742 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL316471 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL99029 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL97926 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL100993 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL101937 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL100533 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL98598 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL101865 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL101977 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL321102 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL98365 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL98612 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL45333 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL317503 | — | IC50 | > | 10000.0 | nM | - |