Assay Detail
Binding
CHEMBL646086
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Concentration that causes 50% inhibition of soluble mammalian alpha-mannosidase in rat liver; NI is less than 50 % inhibition at 1000 uM
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.08 | 4.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2114189 | — | — | 1 | 4.08 |
| CHEMBL312653 | — | — | 1 | - |
| CHEMBL108084 | FAGOMINE | — | 1 | - |
| CHEMBL2115197 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2114189 | — | IC50 | = | 84000.0 | nM | 4.08 |
| CHEMBL312653 | — | IC50 | - | nM | - | |
| CHEMBL108084 | FAGOMINE | IC50 | - | nM | - | |
| CHEMBL2115197 | — | IC50 | - | nM | - |