Assay Detail
Binding
CHEMBL646092
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Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
26
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 4. Structure-activity relationship in the dihydropyrimidine series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 6.29 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL145587 | — | — | 1 | 7.19 |
| CHEMBL436407 | — | — | 1 | 7.10 |
| CHEMBL145770 | — | — | 1 | 6.92 |
| CHEMBL142981 | — | — | 1 | 6.82 |
| CHEMBL145746 | — | — | 1 | 6.75 |
| CHEMBL141322 | — | — | 3 | 6.75 |
| CHEMBL359421 | — | — | 1 | 6.66 |
| CHEMBL145411 | — | — | 1 | 6.36 |
| CHEMBL144534 | — | — | 1 | 6.32 |
| CHEMBL144731 | — | — | 1 | 6.24 |
| CHEMBL357828 | — | — | 1 | 6.24 |
| CHEMBL145278 | — | — | 1 | 6.21 |
| CHEMBL5483012 | — | — | 1 | 6.20 |
| CHEMBL141604 | — | — | 1 | 6.17 |
| CHEMBL357842 | — | — | 1 | 6.16 |
| CHEMBL145353 | — | — | 1 | 6.16 |
| CHEMBL357131 | — | — | 1 | 6.04 |
| CHEMBL142606 | — | — | 1 | 5.96 |
| CHEMBL145001 | — | — | 1 | 5.96 |
| CHEMBL145178 | — | — | 1 | 5.96 |
| CHEMBL359430 | — | — | 1 | 5.80 |
| CHEMBL342347 | — | — | 1 | 5.77 |
| CHEMBL358313 | — | — | 1 | 5.77 |
| CHEMBL142719 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL145587 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL436407 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL145770 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL142981 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL145746 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL141322 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL359421 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL145411 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL144534 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL141322 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL144731 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL357828 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL145278 | — | Ki | = | 610.0 | nM | 6.21 |
| CHEMBL5483012 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL141322 | — | Ki | = | 680.0 | nM | 6.17 |
| CHEMBL141604 | — | Ki | = | 680.0 | nM | 6.17 |
| CHEMBL145353 | — | Ki | = | 690.0 | nM | 6.16 |
| CHEMBL357842 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL357131 | — | Ki | = | 910.0 | nM | 6.04 |
| CHEMBL145001 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL142606 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL145178 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL359430 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL342347 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL358313 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL142719 | — | Ki | = | 1900.0 | nM | 5.72 |