Assay Detail
Binding
CHEMBL646100
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Binding affinity towards human Alpha-1D adrenergic receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Two novel and potent 3-[(o-methoxyphenyl)piperazinylethyl]-5-phenylthien.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 9.16 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL268758 | A-119637 | — | 1 | 9.60 |
| CHEMBL13735 | — | — | 1 | 9.51 |
| CHEMBL13856 | A-123189 | — | 1 | 9.51 |
| CHEMBL13754 | — | — | 1 | 9.33 |
| CHEMBL13647 | BMY-7378 | — | 1 | 9.11 |
| CHEMBL98241 | — | — | 1 | 8.89 |
| CHEMBL14199 | — | — | 1 | 8.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL268758 | A-119637 | Ki | = | 0.252 | nM | 9.60 |
| CHEMBL13735 | — | Ki | = | 0.308 | nM | 9.51 |
| CHEMBL13856 | A-123189 | Ki | = | 0.312 | nM | 9.51 |
| CHEMBL13754 | — | Ki | = | 0.466 | nM | 9.33 |
| CHEMBL13647 | BMY-7378 | Ki | = | 0.778 | nM | 9.11 |
| CHEMBL98241 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL14199 | — | Ki | = | 7.15 | nM | 8.15 |