Assay Detail
Binding
CHEMBL646105
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Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
29
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Phenylacetamides as selective alpha-1A adrenergic receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 5.86 | 7.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL415887 | — | — | 1 | 7.44 |
| CHEMBL435576 | — | — | 1 | 6.89 |
| CHEMBL295304 | — | — | 1 | 6.64 |
| CHEMBL44294 | — | — | 1 | 6.22 |
| CHEMBL42220 | — | — | 1 | 6.15 |
| CHEMBL41677 | — | — | 1 | 6.02 |
| CHEMBL298058 | — | — | 1 | 5.96 |
| CHEMBL297667 | — | — | 1 | 5.96 |
| CHEMBL41844 | — | — | 1 | 5.96 |
| CHEMBL42156 | — | — | 1 | 5.89 |
| CHEMBL289339 | — | — | 1 | 5.89 |
| CHEMBL44124 | — | — | 1 | 5.85 |
| CHEMBL41959 | — | — | 1 | 5.82 |
| CHEMBL41994 | — | — | 3 | 5.80 |
| CHEMBL44496 | — | — | 1 | 5.77 |
| CHEMBL416073 | — | — | 1 | 5.64 |
| CHEMBL417350 | — | — | 1 | 5.62 |
| CHEMBL40303 | — | — | 1 | 5.60 |
| CHEMBL42514 | — | — | 1 | 5.57 |
| CHEMBL42361 | — | — | 1 | 5.54 |
| CHEMBL42763 | — | — | 1 | 5.50 |
| CHEMBL44288 | — | — | 1 | 5.48 |
| CHEMBL296965 | — | — | 1 | 5.48 |
| CHEMBL43799 | — | — | 1 | 5.47 |
| CHEMBL289916 | — | — | 1 | 5.44 |
| CHEMBL43749 | — | — | 1 | 5.20 |
| CHEMBL432302 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL415887 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL435576 | — | Ki | = | 128.0 | nM | 6.89 |
| CHEMBL295304 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL44294 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL42220 | — | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL41677 | — | Ki | = | 960.0 | nM | 6.02 |
| CHEMBL41844 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL298058 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL297667 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL289339 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL42156 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL44124 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL41959 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL41994 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL44496 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL41994 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL416073 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL417350 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL40303 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL41994 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL42514 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL42361 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL42763 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL44288 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL296965 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL43799 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL289916 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL43749 | — | Ki | = | 6300.0 | nM | 5.20 |
| CHEMBL432302 | — | Ki | > | 5000.0 | nM | - |