Assay Detail
Functional
CHEMBL646130
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortex
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Cerebral cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Syntheses and adrenergic activities of ring-fluorinated epinephrines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.53 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL679 | EPINEPHRINE | 4.0 | 1 | 6.40 |
| CHEMBL42359 | — | — | 1 | 6.10 |
| CHEMBL43711 | — | — | 1 | 5.48 |
| CHEMBL287587 | — | — | 1 | 4.15 |
| CHEMBL281232 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL679 | EPINEPHRINE | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL42359 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL43711 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL287587 | — | EC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL281232 | — | EC50 | = | 125000.0 | nM | - |