Assay Detail
Binding
CHEMBL646341
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Compound was evaluated for the inhibitory activity against Human alpha polymerase
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
DNA polymerase alpha catalytic subunit (CHEMBL1828) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Naphthalene carboxamides as inhibitors of human cytomegalovirus DNA polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.60 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29711 | APHIDICOLIN | — | 1 | 5.52 |
| CHEMBL62784 | — | — | 1 | 4.75 |
| CHEMBL65374 | — | — | 1 | 4.50 |
| CHEMBL292775 | — | — | 1 | 4.20 |
| CHEMBL65137 | — | — | 1 | 4.03 |
| CHEMBL66652 | — | — | 1 | - |
| CHEMBL62295 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29711 | APHIDICOLIN | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL62784 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL65374 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL292775 | — | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL65137 | — | IC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL66652 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL62295 | — | IC50 | > | 100000.0 | nM | - |