Assay Detail
Functional
CHEMBL646346
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Tested for functional alpha-antagonist activity against norepinephrine in rabbit aorta and pulmonary artery.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
2,4-Diamino-6,7-dimethoxyquinazolines. 2. 2-(4-Carbamoylpiperidino) derivatives as alpha 1-adrenoceptor antagonists and antihypertensive agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 7.56 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 8.00 |
| CHEMBL6766 | — | — | 1 | 7.42 |
| CHEMBL269537 | — | — | 1 | 7.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2 | PRAZOSIN | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL6766 | — | Kd | = | 38.02 | nM | 7.42 |
| CHEMBL269537 | — | Kd | = | 56.23 | nM | 7.25 |