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Assay Detail

CHEMBL646399

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Aminopeptidase M.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Aminopeptidase N (CHEMBL1907)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Pseudopeptide inhibitors of aminopeptidases containing the [CH(CN)NH] surrogate as a transition-state MIMIC
Luisa Sua rez-Gea M, Garci a-Lo pez T, Pe rez C, Herranz R
Bioorg Med Chem Lett (1994) 4 : 1491 -1496
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 5.16 5.62

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL288458 1 5.62
CHEMBL35092 1 5.54
CHEMBL37281 1 5.47
CHEMBL35627 1 5.42
CHEMBL36081 1 5.30
CHEMBL29292 UBENIMEX 2.0 1 4.71
CHEMBL37572 1 4.07
CHEMBL2372318 1 -
CHEMBL35660 1 -
CHEMBL34777 1 -
CHEMBL289761 1 -
CHEMBL290459 1 -
CHEMBL287539 1 -
CHEMBL35542 1 -
CHEMBL287482 1 -
CHEMBL34258 1 -
CHEMBL37879 1 -
CHEMBL287968 1 -
CHEMBL35202 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL288458 IC50 = 2400.0 nM 5.62
CHEMBL35092 IC50 = 2900.0 nM 5.54
CHEMBL37281 IC50 = 3400.0 nM 5.47
CHEMBL35627 IC50 = 3800.0 nM 5.42
CHEMBL36081 IC50 = 5000.0 nM 5.30
CHEMBL29292 UBENIMEX IC50 = 19400.0 nM 4.71
CHEMBL37572 IC50 = 85000.0 nM 4.07
CHEMBL2372318 IC50 = 793000.0 nM -
CHEMBL35660 IC50 = 1000000.0 nM -
CHEMBL34777 IC50 = 146000.0 nM -
CHEMBL289761 IC50 = 1000000.0 nM -
CHEMBL290459 IC50 = 1000000.0 nM -
CHEMBL287539 IC50 = 1000000.0 nM -
CHEMBL35542 IC50 = 1000000.0 nM -
CHEMBL287482 IC50 = 1000000.0 nM -
CHEMBL34258 IC50 = 1000000.0 nM -
CHEMBL37879 IC50 = 1000000.0 nM -
CHEMBL287968 IC50 = 1000000.0 nM -
CHEMBL35202 IC50 = 1000000.0 nM -