Assay Detail
Binding
CHEMBL646404
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Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell line
37
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | MOLT-4 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Nonpeptide small-molecular inhibitors of dipeptidyl peptidase IV: N-phenylphthalimide analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 4.46 | 4.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL88474 | — | — | 2 | 4.88 |
| CHEMBL90558 | — | — | 2 | 4.78 |
| CHEMBL151999 | — | — | 2 | 4.54 |
| CHEMBL88953 | — | — | 2 | 4.49 |
| CHEMBL153096 | — | — | 2 | 4.46 |
| CHEMBL424612 | — | — | 2 | 4.42 |
| CHEMBL313952 | — | — | 2 | 4.33 |
| CHEMBL283880 | — | — | 2 | 4.25 |
| CHEMBL153037 | — | — | 2 | 4.01 |
| CHEMBL153236 | — | — | 1 | - |
| CHEMBL315471 | — | — | 2 | - |
| CHEMBL152529 | — | — | 1 | - |
| CHEMBL91130 | — | — | 1 | - |
| CHEMBL151461 | — | — | 2 | - |
| CHEMBL329471 | — | — | 2 | - |
| CHEMBL89081 | — | — | 1 | - |
| CHEMBL8916 | — | — | 1 | - |
| CHEMBL113918 | — | — | 1 | - |
| CHEMBL29292 | UBENIMEX | 2.0 | 2 | - |
| CHEMBL345319 | — | — | 2 | - |
| CHEMBL90616 | — | — | 1 | - |
| CHEMBL277841 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL88474 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL90558 | — | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL151999 | — | IC50 | = | 28800.0 | nM | 4.54 |
| CHEMBL88953 | — | IC50 | = | 32500.0 | nM | 4.49 |
| CHEMBL153096 | — | IC50 | = | 34500.0 | nM | 4.46 |
| CHEMBL424612 | — | IC50 | = | 38500.0 | nM | 4.42 |
| CHEMBL313952 | — | IC50 | = | 46400.0 | nM | 4.33 |
| CHEMBL283880 | — | IC50 | = | 56300.0 | nM | 4.25 |
| CHEMBL153037 | — | IC50 | = | 98400.0 | nM | 4.01 |
| CHEMBL88474 | — | IC50 | = | 4.3 | ug.mL-1 | - |
| CHEMBL315471 | — | IC50 | = | 108900.0 | nM | - |
| CHEMBL113918 | — | IC50 | > | 100.0 | ug.mL-1 | - |
| CHEMBL29292 | UBENIMEX | IC50 | > | 471600.0 | nM | - |
| CHEMBL29292 | UBENIMEX | IC50 | > | 100.0 | ug.mL-1 | - |
| CHEMBL345319 | — | IC50 | = | 133900.0 | nM | - |
| CHEMBL345319 | — | IC50 | = | 38.2 | ug.mL-1 | - |
| CHEMBL90616 | — | IC50 | > | 100.0 | ug.mL-1 | - |
| CHEMBL277841 | — | IC50 | = | 264500.0 | nM | - |
| CHEMBL277841 | — | IC50 | = | 70.7 | ug.mL-1 | - |
| CHEMBL8916 | — | IC50 | > | 100.0 | ug.mL-1 | - |
| CHEMBL315471 | — | IC50 | = | 29.0 | ug.mL-1 | - |
| CHEMBL90558 | — | IC50 | = | 5.4 | ug.mL-1 | - |
| CHEMBL152529 | — | IC50 | > | 100.0 | ug.mL-1 | - |
| CHEMBL153236 | — | IC50 | > | 100.0 | ug.mL-1 | - |
| CHEMBL89081 | — | IC50 | > | 100.0 | ug.mL-1 | - |
| CHEMBL329471 | — | IC50 | > | 100.0 | ug.mL-1 | - |
| CHEMBL329471 | — | IC50 | = | 309200.0 | nM | - |
| CHEMBL151461 | — | IC50 | > | 100.0 | ug.mL-1 | - |
| CHEMBL151461 | — | IC50 | > | 471600.0 | nM | - |
| CHEMBL91130 | — | IC50 | > | 100.0 | ug.mL-1 | - |
| CHEMBL153096 | — | IC50 | = | 10.2 | ug.mL-1 | - |
| CHEMBL313952 | — | IC50 | = | 15.0 | ug.mL-1 | - |
| CHEMBL424612 | — | IC50 | = | 10.3 | ug.mL-1 | - |
| CHEMBL151999 | — | IC50 | = | 11.4 | ug.mL-1 | - |
| CHEMBL153037 | — | IC50 | = | 40.5 | ug.mL-1 | - |
| CHEMBL283880 | — | IC50 | = | 15.0 | ug.mL-1 | - |
| CHEMBL88953 | — | IC50 | = | 9.6 | ug.mL-1 | - |