Assay Detail
Binding
CHEMBL646440
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125 I]AB-MECA from human Adenosine A3 receptor expressed in HEK cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Chiral resolution and stereospecificity of 6-phenyl-4-phenylethynyl- 1,4-dihydropyridines as selective A(3) adenosine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.94 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2111655 | — | — | 1 | 6.28 |
| CHEMBL2112436 | — | — | 1 | 6.19 |
| CHEMBL2051956 | DEXNIGULDIPINE | 2.0 | 1 | 5.72 |
| CHEMBL405355 | NIGULDIPINE | 2.0 | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2111655 | — | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL2112436 | — | Ki | = | 650.0 | nM | 6.19 |
| CHEMBL2051956 | DEXNIGULDIPINE | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL405355 | NIGULDIPINE | Ki | = | 2800.0 | nM | 5.55 |